Zipper J, Dabancens A, Guerrero A, Trujillo V
Department of Physiology and Biophysics, Faculty of Medicine, University of Chile and Sotero del Rio Hospital, Santiago.
Int J Gynaecol Obstet. 1995 Dec;51 Suppl 1:S47-55. doi: 10.1016/0020-7292(95)90369-0.
Quinacrine, an acridine derivative that was in widespread use as an anti-malarial, has been shown to have both sclerosant and anticarcinogenic actions. The sclerosant action of quinacrine has been used to produce occlusion of Fallopian tube in both experimental animals and women, and several clinical studies are reviewed. Both actions of quinacrine are potentiated by steroidal and non-steroidal antiprostaglandins as well as by ionic copper. Combinations of quinacrine with antiprostaglandin drugs, and also with copper, improved the efficacy of quinacrine when used for female sterilization and reduced side effects. A review of the experimental and epidemiological evidence suggests that quinacrine has no carcinogenic effects.
喹吖因是一种曾被广泛用作抗疟药的吖啶衍生物，已被证明具有硬化剂和抗癌作用。喹吖因的硬化剂作用已被用于在实验动物和女性中造成输卵管闭塞，本文回顾了几项临床研究。喹吖因的这两种作用都可被甾体和非甾体类抗前列腺素以及离子铜增强。喹吖因与抗前列腺素药物以及与铜的联合使用，在用于女性绝育时提高了喹吖因的疗效并减少了副作用。对实验和流行病学证据的回顾表明，喹吖因没有致癌作用。
