Hua Q, Wang J R, Shi S Y
Xuanwu Hospital, Capital Institute of Medicine, Beijing.
Zhonghua Nei Ke Za Zhi. 1994 Mar;33(3):165-7.
Heart function and plasma atrial natriuretic peptide (ANP), plasma renin activity (PRA) and angiotension II (Ang II) were examined with echocardiography and radioimmunoassay in 9 patients with dilated cardiomyopathy (DCM), 41 with rheumatic heart disease (RHD), 29 with hyperthyroidism (Ht) and 24 normal subjects. ANP level was significantly increased as heart failure progressed (P < 0.01 and 0.001). There was negative correlation between ANP and left ventricular fractional shortening, and between ANP and ejection fraction in DCM and Ht groups. There was positive correlation between ANP and maximal left atrial diameter, right atrial area, and diastolic diameter or volume of left ventricle in DCM and RHD groups, and negative correlation between ANP and peak flow velocity in aorta or through mitral valve in DCM group (r = -0.608, P < 0.05 and r = 0.710, P < 0.05). These findings suggest that the stronger the myocardial contractility and the faster the blood flow, the lower the plasma ANP level.
采用超声心动图和放射免疫分析法，对9例扩张型心肌病（DCM）患者、41例风湿性心脏病（RHD）患者、29例甲状腺功能亢进症（Ht）患者及24名正常受试者的心脏功能以及血浆心房利钠肽（ANP）、血浆肾素活性（PRA）和血管紧张素II（Ang II）进行了检测。随着心力衰竭的进展，ANP水平显著升高（P < 0.01和0.001）。在DCM组和Ht组中，ANP与左心室缩短分数以及ANP与射血分数之间呈负相关。在DCM组和RHD组中，ANP与最大左心房直径、右心房面积以及左心室舒张直径或容积呈正相关，而在DCM组中，ANP与主动脉或二尖瓣峰值流速呈负相关（r = -0.608，P < 0.05；r = 0.710，P < 0.05）。这些发现表明，心肌收缩力越强、血流速度越快，血浆ANP水平越低。
