Fu P, Li M Y
Department of Ophthalmology, First Clinical Hospital, Beijing Medical University.
Zhonghua Yan Ke Za Zhi. 1994 Sep;30(5):369-72.
The lamina cribrosa of 15 normal adult human eyes were observed by scanning electron microscopy and their images were analyzed by a computerized system to study the distribution of pores and the proportion of connective tissue in different regions of the lamina cribrosa. The results revealed that there are significantly more large pores (> or = 3,000 microns2) in the superior and inferior than those in the nasal and temporal quadrants, especially in the peripheral regions, however, in terms of area the percentages of connective tissue in the nasal and temporal quadrants are the highest. In addition, the histological study of the lamina cribrosa disclosed that the collagenous fibers, various in calibre, are arranged in bundles and tangentially around each pore. Since the nerve fiber damage in glaucoma initially occurs at the superior and inferior parts of the optic nerve, the above anatomical characteristics possibly can explain the cause of the visual field defects in early glaucoma.
采用扫描电子显微镜观察15只正常成人眼的筛板，并通过计算机系统分析其图像，以研究筛板不同区域的孔隙分布及结缔组织比例。结果显示，上下象限的大孔隙（≥3000平方微米）明显多于鼻侧和颞侧象限，尤其是周边区域；然而，就面积而言，鼻侧和颞侧象限的结缔组织百分比最高。此外，筛板的组织学研究表明，粗细各异的胶原纤维呈束状排列，并围绕每个孔隙呈切线状分布。由于青光眼患者的神经纤维损伤最初发生在视神经的上下部分，上述解剖学特征可能可以解释早期青光眼视野缺损的原因。
