Panyutich A V, Szold O, Poon P H, Tseng Y, Ganz T
Will Rogers Pulmonary Research Laboratory, University of California at Los Angeles 90024-1736.
FEBS Lett. 1994 Dec 19;356(2-3):169-73. doi: 10.1016/0014-5793(94)01261-x.
In human serum we found strong defensin binding to the complexes of activated C1 complement (C1) and C1 inhibitor (C1i). Purified C1q, activated C1 tetramer (r2s2) and C1i did not bind defensin. When r2s2 was dissociated by EDTA, only the activated C1s (C1s) bound defensin. Binding of defensins to C1 complement represents a newly recognized bridge between the complement- and phagocyte-mediated host defenses, and a potential mechanism for protecting infected tissue from cytotoxic injury by defensin.
在人血清中，我们发现防御素与活化的C1补体（C1）和C1抑制剂（C1i）的复合物有强烈结合。纯化的C1q、活化的C1四聚体（r2s2）和C1i不结合防御素。当r2s2被EDTA解离时，只有活化的C1s（C1s）结合防御素。防御素与C1补体的结合代表了补体和吞噬细胞介导的宿主防御之间新发现的桥梁，以及保护感染组织免受防御素细胞毒性损伤的潜在机制。
