Sengoku K, Satoh T, Saitoh S, Abe M, Ishikawa M
Department of Obstetrics and Gynecology, Asahikawa Medical College, Japan.
Int J Gynaecol Obstet. 1994 Jul;46(1):39-43. doi: 10.1016/0020-7292(94)90307-7.
To evaluate the efficacy of color Doppler ultrasonography as the predictor of malignant ovarian tumors and to compare the results with CA 125 levels and ultrasonographic morphological patterns.
We compared color Doppler ultrasound with sonographic findings and serum CA 125 levels for predicting ovarian malignancy in 16 patients with malignant and 12 patients with benign ovarian tumors.
There was a significant difference in pulsatility index (PI) value of ovarian vessel between benign and malignant tumors (2.42 +/- 0.67 for benign and 1.35 +/- 0.78 for malignant, respectively, P < 0.01). The specificity of morphological findings and CA 125 was lower than that of PI measurements, but sensitivity was not different between the three methods. In addition, the combination of color Doppler and CA 125 or morphological assessments resulted in a sensitivity of 100% and a negative predictive value of 100%, respectively.
PI measurements by transvaginal color Doppler ultrasound combined with CA 125 levels or morphological findings could be an accurate and appropriate screening method for ovarian tumors.
评估彩色多普勒超声作为恶性卵巢肿瘤预测指标的有效性，并将结果与CA 125水平及超声形态学模式进行比较。
我们将16例恶性卵巢肿瘤患者和12例良性卵巢肿瘤患者的彩色多普勒超声结果与超声检查结果及血清CA 125水平进行比较，以预测卵巢恶性肿瘤。
良性和恶性肿瘤之间卵巢血管的搏动指数（PI）值存在显著差异（良性分别为2.42±0.67，恶性为1.35±0.78，P<0.01）。形态学表现和CA 125的特异性低于PI测量，但三种方法之间的敏感性无差异。此外，彩色多普勒与CA 125或形态学评估相结合，敏感性分别为100%，阴性预测值为100%。
经阴道彩色多普勒超声测量PI值结合CA 125水平或形态学表现可能是一种准确且合适的卵巢肿瘤筛查方法。
