Remacha A F, Ordoñez J, Barcelo M J, Garcia-Die F, Arza B, Estruch A
Hematology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Haematologica. 1994 Jul-Aug;79(4):350-2.
To evaluate the role of erythropoietin (Epo) in the erythroid abnormalities often found in athletes, Epo was evaluated by radioimmunoassay in endurance runners (ER). In a first study, 46 experienced ER, 11 with iron deficiency (ID group), were studied during a training period. In ID and non-ID runners, serum Epo (SEpo) levels were similar to sedentary controls (ID = 19.1 +/- 4.9 U/L, non-ID = 19.7 +/- 5.5 U/L and controls 19.7 +/- 9.2 U/L). In a second study, serum and urine erythropoietin (UEpo) levels were evaluated in 17 ER during a 6-hour race. Samples were taken before the race (pre-race), immediately following (6-hour) and 4 days after (post-race). No differences were observed in SEpo levels (pre-race = 19.8 +/- 4.1 U/L, 6-hour = 21.2 +/- 4.9 U/L and post-race = 21 +/- 4 U/L), but UEpo increased following the race (pre-race = 15.4 +/- 9.6 U/L, 6-hour = 26.1 +/- 6.2 U/L and post-race = 14.1 +/- 6.5 U/L) (p < 0.0001) and this UEpo increase was related to urine creatinine changes (rs = 0.79, p < 0.00001). In conclusion, SEpo in ER does not differ from sedentary values and does not vary with competition; however, UEpo increases during a long-distance race. These data may be important for a correct evaluation of Epo abusers and sports anemia.
为评估促红细胞生成素（Epo）在运动员中常见的红系异常中的作用，通过放射免疫分析法对耐力跑运动员（ER）的Epo进行了评估。在第一项研究中，对46名有经验的耐力跑运动员进行了研究，其中11名患有缺铁性贫血（ID组），研究时间为一个训练期。在缺铁性贫血和非缺铁性贫血的跑步者中，血清Epo（SEpo）水平与久坐不动的对照组相似（ID组 = 19.1±4.9 U/L，非ID组 = 19.7±5.5 U/L，对照组 = 19.7±9.2 U/L）。在第二项研究中，对17名耐力跑运动员在6小时比赛期间的血清和尿促红细胞生成素（UEpo）水平进行了评估。在比赛前（赛前）、比赛结束后立即（6小时）和比赛后4天采集样本。SEpo水平未观察到差异（赛前 = 19.8±4.1 U/L，6小时 = 21.2±4.9 U/L，赛后 = 21±4 U/L），但比赛后UEpo增加（赛前 = 15.4±9.6 U/L，6小时 = 26.1±6.2 U/L，赛后 = 14.1±6.5 U/L）（p < 0.0001），并且这种UEpo增加与尿肌酐变化有关（rs = 0.79，p < 0.00001）。总之，耐力跑运动员的SEpo与久坐不动者的值无差异，且不随比赛而变化；然而，在长跑过程中UEpo会增加。这些数据对于正确评估Epo滥用者和运动性贫血可能很重要。
