小鼠肺泡肺肿瘤的一个易感基因定位在H2复合体内的Hsp70.3和G7之间。

A susceptibility gene for alveolar lung tumors in the mouse maps between Hsp70.3 and G7 within the H2 complex.

作者信息

Fijneman R J, Oomen L C, Snoek M, Demant P

机构信息

The Netherlands Cancer Institute, Division of Molecular Genetics, Amsterdam.

出版信息

Immunogenetics. 1995;41(2-3):106-9. doi: 10.1007/BF00182320.

DOI:10.1007/BF00182320

PMID:7806281

Abstract

Lung tumor susceptibility (LTS) in the mouse is influenced by multiple loci within the H2 complex. We compared the LTS of two H2 congenic strains with intra H2 recombinations, B10.A(1R) and B10.A(2R), whose genetic difference has been reduced to a region of approximately 50 kilobases within the C4-H2D interval, between Hsp70.3 and G7. After transplacental induction with N-ethyl-N-nitrosourea the load of alveolar lung tumors in strain B10.A(2R) is significantly higher than in strain B10.A(1R) (P < 0.001). For papillary tumors no significant differences were observed. We conclude that the alveolar lung tumor load is influenced by an LTS gene located within the Hsp70.3-G7 interval.

摘要

小鼠的肺肿瘤易感性（LTS）受H2复合体内多个基因座的影响。我们比较了两个具有H2内部重组的H2同源品系B10.A(1R)和B10.A(2R)的LTS，它们的遗传差异已缩小到C4 - H2D区间内约50千碱基的区域，位于Hsp70.3和G7之间。在用N - 乙基 - N - 亚硝基脲进行经胎盘诱导后，B10.A(2R)品系的肺泡肺肿瘤负荷显著高于B10.A(1R)品系（P < 0.001）。对于乳头状肿瘤，未观察到显著差异。我们得出结论，肺泡肺肿瘤负荷受位于Hsp70.3 - G7区间内的一个LTS基因影响。