散射因子与c-met受体：间充质/上皮相互作用的范例
Scatter factor and the c-met receptor: a paradigm for mesenchymal/epithelial interaction.
作者信息
Rosen E M, Nigam S K, Goldberg I D
机构信息
Long Island Jewish Medical Center, Long Island Campus for Albert Einstein College of Medicine, Department of Radiation Oncology, New Hyde Park, New York 11042.
出版信息
J Cell Biol. 1994 Dec;127(6 Pt 2):1783-7. doi: 10.1083/jcb.127.6.1783.
Abstract
Epithelia and mesenchyme interact during various physiologic and pathologic processes. Scatter factor is a mesenchyme-derived cytokine that stimulates motility, proliferation, and morphogenesis of epithelia. Recent studies suggest that scatter factor and its receptor (c-met) mediate mesenchyme/epithelia signalling and even interconversion. In this mini-review, we will discuss how scatter factor and c-met may mediate interactions between mesenchyme and epithelia during embryogenesis, organ repair, and neoplasia.
摘要
上皮组织和间充质在各种生理和病理过程中相互作用。散射因子是一种间充质来源的细胞因子，可刺激上皮组织的运动、增殖和形态发生。最近的研究表明，散射因子及其受体（c-met）介导间充质/上皮信号传导，甚至相互转化。在这篇小型综述中，我们将讨论散射因子和c-met如何在胚胎发生、器官修复和肿瘤形成过程中介导间充质和上皮之间的相互作用。
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