Guerrero J M, Reiter R J, Poeggeler B, Chen L D, Tan D X
Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio 78284-7762.
J Pineal Res. 1994 May;16(4):210-4. doi: 10.1111/j.1600-079x.1994.tb00104.x.
The present paper reports that nitric oxide (NO) released by sodium nitroprusside (SNP) is a potent activator of rat pineal cyclic GMP production without affecting cyclic AMP synthesis. Other drugs such as isoproterenol, vasoactive intestinal peptide, and peptide histidine isoleucine were ineffective in stimulating cyclic GMP production, but activated cyclic AMP production. However, L-arginine, the physiological precursor of NO, did not activate either cyclic GMP or NO synthesis. Because L-arginine failed to activate cyclic GMP production, results suggest that NO is not produced in the pineal gland, but behaves as a potent regulator of this cyclic nucleotide.
本文报道硝普钠（SNP）释放的一氧化氮（NO）是大鼠松果体环磷酸鸟苷（cGMP）生成的强效激活剂，而不影响环磷酸腺苷（cAMP）的合成。其他药物如异丙肾上腺素、血管活性肠肽和肽组氨酸异亮氨酸在刺激cGMP生成方面无效，但能激活cAMP生成。然而，NO的生理前体L-精氨酸既不激活cGMP生成也不激活NO合成。由于L-精氨酸未能激活cGMP生成，结果表明NO并非在松果体中产生，而是作为这种环核苷酸的强效调节剂发挥作用。
