Kuwabara Y, Ichiya Y, Ichimiya A, Sasaki M, Akashi Y, Yoshida T, Fukumura T, Masuda K
Department of Radiology, Faculty of Medicine Kyushu University, Fukuoka.
Kaku Igaku. 1994 Oct;31(10):1255-60.
We studied the serial changes of CMRGlu in 6 patients with dementia of Alzheimer type. All patients demonstrated moderately severe dementia at the initial PET scan. Serial PET scans were performed at an interval of 12 to 24 months. Five of the 6 patients showed a deterioration of clinical symptoms at the second scan. The global CMRGlu serially decreased in all patients. An asymmetry of CMRGlu in both the frontal and parietal regions was observed at the initial PET scan, while the direction of asymmetry was preserved at the second PET scan. The ratios (frontal/parietal and parietal/striatum) of CMRGlu showed no interval change. Therefore, CMRGlu was considered to decrease progressively throughout the entire brain in patients with moderately severe dementia of Alzheimer type.
我们研究了6例阿尔茨海默病型痴呆患者脑代谢率葡萄糖（CMRGlu）的系列变化。所有患者在初次正电子发射断层扫描（PET）时均表现为中度严重痴呆。PET扫描系列检查每隔12至24个月进行一次。6例患者中有5例在第二次扫描时临床症状恶化。所有患者的全脑CMRGlu均呈系列性下降。初次PET扫描时在额叶和顶叶区域均观察到CMRGlu不对称，而在第二次PET扫描时不对称方向得以保留。CMRGlu的比率（额叶/顶叶和顶叶/纹状体）没有间隔变化。因此，对于中度严重阿尔茨海默病型痴呆患者，CMRGlu被认为在整个大脑中逐渐降低。
