Royds J A, Silcocks P B, Rees R C, Stephenson T J
Department of Pathology, University of Sheffield Medical School, England.
Pathologica. 1994 Jun;86(3):240-3.
The nm23 gene production has been heralded as a suppressor of metastasis in many human tumours but it is not clear at which stage in the metastatic process nm23 protein exerts its effect. The aim of this study was to test whether nm23 protein is associated with occurrence or category of angioinvasion. We have made use of the well documented fact that follicular carcinoma of the thyroid may show vascular invasion whereas papillary carcinomas may metastasis via the lymphatics. 65 thyroid tumours (20 follicular adenomas, 22 papillary carcinomas, 23 follicular carcinomas) were stained for nm23 protein using an immunopurified polyclonal antibody. Nm23 protein status showed no correlation with category of thyroid tumour. This is indirect evidence that nm23 does not suppress metastasis by influencing vascular invasion in this tumour type.
nm23基因产物在许多人类肿瘤中被视为转移抑制因子，但尚不清楚nm23蛋白在转移过程的哪个阶段发挥作用。本研究的目的是测试nm23蛋白是否与血管侵犯的发生或类型相关。我们利用了甲状腺滤泡癌可能表现出血管侵犯而乳头状癌可能通过淋巴管转移这一有充分文献记载的事实。使用免疫纯化的多克隆抗体对65例甲状腺肿瘤（20例滤泡性腺瘤、22例乳头状癌、23例滤泡癌）进行nm23蛋白染色。nm23蛋白状态与甲状腺肿瘤类型无关。这间接证明nm23在这种肿瘤类型中并非通过影响血管侵犯来抑制转移。
