Bertheau P, De La Rosa A, Steeg P S, Merino M J
Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892.
Am J Pathol. 1994 Jul;145(1):26-32.
The expression of nm23 gene products has been associated with a lower metastatic potential and better outcome in malignant tumors. We have used immunohistochemistry to study the expression of nm23 protein in thyroid tissues from 101 patients consisting of 78 malignant neoplasms, 13 adenomas, and 10 other benign conditions. Cytoplasmic staining for nm23 protein was identified in normal tissues and in most benign and malignant lesions and did not correlate with either histological type of clinical outcome. Nuclear staining was seen in 93% of normal tissues and in 29% of primary carcinomas of the thyroid and was associated with a longer disease-free survival (P = 0.03). Membranous staining was present in some tumors but absent in normal thyroid. In conclusion, nm23 protein has a combined pattern of distribution among subcellular compartments in thyroid tissues. Although there was no significant association between cytoplasmic or membranous expression and histological type of tumor or survival nm23 nuclear expression may be a useful marker in assessing the evolution of thyroid tumors.
nm23基因产物的表达与恶性肿瘤较低的转移潜能及较好的预后相关。我们采用免疫组织化学方法研究了101例患者甲状腺组织中nm23蛋白的表达情况，其中包括78例恶性肿瘤、13例腺瘤和10例其他良性病变。在正常组织以及大多数良性和恶性病变中均发现了nm23蛋白的细胞质染色，且其与临床结局的组织学类型均无相关性。在93%的正常组织和29%的甲状腺原发性癌中可见细胞核染色，且其与较长的无病生存期相关（P = 0.03）。一些肿瘤中存在细胞膜染色，但正常甲状腺组织中无此现象。总之，nm23蛋白在甲状腺组织的亚细胞区室中具有复合分布模式。虽然细胞质或细胞膜表达与肿瘤组织学类型或生存率之间无显著相关性，但nm23细胞核表达可能是评估甲状腺肿瘤进展的一个有用标志物。
