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Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12362-4. doi: 10.1073/pnas.91.26.12362.
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Tetramethylbenzidine: An Acoustogenic Photoacoustic Probe for Reactive Oxygen Species Detection.四甲基联苯胺：用于活性氧物种检测的声致光声探针。
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The effect of reagents mimicking oxidative stress on fibrinogen function.模拟氧化应激的试剂对纤维蛋白原功能的影响。
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Novel products generated from 2'-deoxyguanosine by hypochlorous acid or a myeloperoxidase-H2O2-Cl- system: identification of diimino-imidazole and amino-imidazolone nucleosides.由次氯酸或髓过氧化物酶-H2O2-Cl-系统作用于2'-脱氧鸟苷产生的新型产物：二亚氨基咪唑和氨基咪唑酮核苷的鉴定。
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Hypochlorous acid stress in Escherichia coli: resistance, DNA damage, and comparison with hydrogen peroxide stress.大肠杆菌中的次氯酸应激：抗性、DNA损伤以及与过氧化氢应激的比较。
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9
Susceptibility of cloned K+ channels to reactive oxygen species.克隆的钾离子通道对活性氧的敏感性。
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Direct spectroscopic observation of singlet oxygen emission at 1268 nm excited by sensitizing dyes of biological interest in liquid solution.在液体溶液中，通过具有生物学意义的敏化染料激发，对1268纳米处单线态氧发射进行直接光谱观测。
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Myeloperoxidase singlet molecular oxygen generation detected by direct infrared electronic emission.通过直接红外电子发射检测髓过氧化物酶单线态分子氧的产生。
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The role of chloride ion in photosynthesis. 3. The effect of artificial electron donors upon electron transport.氯离子在光合作用中的作用。3. 人工电子供体对电子传递的影响。
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Singlet oxygen induces frank strand breaks as well as alkali- and piperidine-labile sites in supercoiled plasmid DNA.
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Nucleotide chloramines and neutrophil-mediated cytotoxicity.核苷酸氯胺与中性粒细胞介导的细胞毒性。
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Biological consequences associated with DNA oxidation mediated by singlet oxygen.
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Chlorination, chlorination by-products, and cancer: a meta-analysis.氯化、氯化副产物与癌症：一项荟萃分析。
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次氯酸盐水溶液简单酸化时单重态分子氧的产生：应用于氯化饮用水对健康有害影响的研究。

Singlet molecular oxygen evolution upon simple acidification of aqueous hypochlorite: application to studies on the deleterious health effects of chlorinated drinking water.

作者信息

Khan A U, Kasha M

机构信息

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138.

出版信息

Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12362-4. doi: 10.1073/pnas.91.26.12362.

DOI:10.1073/pnas.91.26.12362
PMID:7809041
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC45437/
Abstract

A study of the pH profile of the decomposition of aqueous hypochlorite has revealed the evolution (onset at pH 8) of single (1 delta g) molecular oxygen (singlet spin state dioxygen) detected spectroscopically (1268 nm), prior to the appearance of chlorine (onset at pH 5.5). The possible mechanism of the singlet state dioxygen evolution is presented, and the origin of its chloride ion dependence is discussed, especially in reference to chloride ion dependence of singlet molecular oxygen evolution in biological systems. Recent epidemiological analyses of the correlation of human cancer with chlorinated water supplies focus attention on the singlet oxygen mechanisms of DNA lesion formation.

摘要

一项关于次氯酸盐水溶液分解的pH值曲线研究表明，在氯出现（起始pH值为5.5）之前，通过光谱检测（1268纳米）发现了单重态（1Δg）分子氧（单重自旋态双氧）的生成（起始pH值为8）。文中提出了单重态双氧生成的可能机制，并讨论了其对氯离子依赖性的起源，特别是参照了生物系统中生成单重态分子氧对氯离子的依赖性。最近关于人类癌症与氯化供水相关性的流行病学分析，将注意力集中在DNA损伤形成的单线态氧机制上。