哈伯-维希反应中的单线态分子氧。
Singlet molecular oxygen in the Haber-Weiss reaction.
作者信息
Khan A U, Kasha M
机构信息
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138.
出版信息
Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12365-7. doi: 10.1073/pnas.91.26.12365.
Abstract
Characteristic chemiluminescence emission of singlet (1 delta g) molecular oxygen at 1268 nm is reported from a Haber-Weiss reaction. The reaction consists of mixing aqueous hydrogen peroxide with a solution of potassium superoxide, solubilized by 18-crown-6 ether in carbon tetrachloride or in dry acetonitrile at room temperature. Since the discovery of the enzyme superoxide dismutase by J.M. McCord and I. Fridovich [(1968) J. Biol. Chem. 243, 5733-5760], the identity of the reactive oxidant in superoxide-generating systems in biology has remained a chemical mystery. The results presented here suggest strongly that the reactive species is singlet oxygen generated via the Haber-Weiss reaction and not, as usually assumed, the hydroxyl radical, .OH, generated by the same reaction.
摘要
据报道，哈伯-维希反应会产生波长为1268纳米的单线态（1Δg）分子氧的特征化学发光。该反应是在室温下，将过氧化氢水溶液与超氧化钾溶液混合，超氧化钾由18-冠-6醚溶解于四氯化碳或干燥乙腈中。自J.M.麦考德和I.弗里多维奇发现超氧化物歧化酶[（1968年）《生物化学杂志》243卷，5733 - 5760页]以来，生物中超氧化物生成系统中活性氧化剂的身份一直是个化学谜团。此处给出的结果有力地表明，活性物种是通过哈伯-维希反应生成的单线态氧，而不是通常所认为的由同一反应生成的羟基自由基·OH。
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