塞内加尔番荔枝种子的细胞毒性和抗寄生虫活性。

Cytotoxic and antiparasitic activity from Annona senegalensis seeds.

作者信息

Sahpaz S, Bories C, Loiseau P M, Cortès D, Hocquemiller R, Laurens A, Cavé A

机构信息

Laboratoire de Pharmacognosie, URA CNRS 496, Faculté de Pharmacie, Université Paris-Sud, Châtenay-Malabry, France.

出版信息

Planta Med. 1994 Dec;60(6):538-40. doi: 10.1055/s-2006-959566.

DOI:10.1055/s-2006-959566

PMID:7809207

Abstract

Several extracts of Annona senegalensis (Annonaceae) seeds were tested for antiparasitic activity against Leishmania major, Leishmania donovani, Trypanosoma brucei brucei, and for cytotoxic activity against KB and VERO cell lines. Fractionation of seeds extracts was mainly guided by means of a biocidal assay against Artemia salina nauplii. The biological activities resulted from extract-isolated acetogenins.

摘要

对塞内加尔番荔枝（番荔枝科）种子的几种提取物进行了测试，检测其对硕大利什曼原虫、杜氏利什曼原虫、布氏布氏锥虫的抗寄生虫活性，以及对KB和VERO细胞系的细胞毒性活性。种子提取物的分级分离主要通过针对卤虫无节幼体的杀菌试验来指导。生物活性源于提取物分离出的产乙酸素。