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运动诱发的哮喘和过敏反应。

Exercise-induced asthma and anaphylaxis.

作者信息

Hough D O, Dec K L

机构信息

Michigan State University Sports Medicine, East Lansing.

出版信息

Sports Med. 1994 Sep;18(3):162-72. doi: 10.2165/00007256-199418030-00003.

Abstract

With increased popularity in exercise, the number of individuals with exercise-induced asthma (EIA), or 'exercise-induced bronchospasm', has increased due to an increased awareness among physicians of the clinical symptoms associated with EIA. EIA affects approximately 75 to 95% of asthmatic patients. 40% of children with allergic rhinitis have EIA, whereas only 3 to 11% of nonasthmatics have EIA. Although athletes with asthma have been recognised for years, EIA in nonasthmatic individuals has gained recognition since the 1984 Olympics. Vague symptoms of recurring poor performance, fatigue despite adequate conditioning, or 'getting winded' during an athlete's usual workout may be the presenting complaints. Athletes may be more likely to attribute these symptoms to poor conditioning or an upper respiratory infection, and not seek immediate assistance. Younger athletes may complain of stomach ache or refuse to participate in strenuous play because of an inability to keep up with other children. Additionally, an awareness of exercise-induced anaphylaxis needs to be considered when discussing aspects of airway compromise following exercise; however, its presentation is more urgent than those with EIA. Although the pathophysiology of EIA is somewhat controversial, the most likely explanation is a combination of heat and water loss leading to mediator release. The different medications that have been used to treat EIA are based on theories regarding the bronchial hyperreactivity of EIA.

摘要

随着运动越来越普及,由于医生对与运动诱发性哮喘(EIA)相关临床症状的认识提高,患有运动诱发性哮喘或“运动诱发性支气管痉挛”的人数有所增加。EIA影响约75%至95%的哮喘患者。40%的过敏性鼻炎儿童患有EIA,而非哮喘患者中只有3%至11%患有EIA。尽管哮喘运动员已被认识多年,但非哮喘个体中的EIA自1984年奥运会以来才得到认可。反复表现不佳、尽管体能良好仍感到疲劳或在运动员日常训练中“气喘吁吁”等模糊症状可能是就诊主诉。运动员可能更倾向于将这些症状归因于体能不佳或上呼吸道感染,而不寻求立即帮助。较年轻的运动员可能会抱怨肚子疼或因跟不上其他孩子而拒绝参加剧烈运动。此外,在讨论运动后气道受损的相关问题时,需要考虑运动诱发性过敏反应;然而,其表现比EIA更为紧急。尽管EIA的病理生理学存在一定争议,但最可能的解释是热量和水分流失导致介质释放。用于治疗EIA的不同药物是基于有关EIA支气管高反应性的理论。

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