Sheen-Chen S M, Cheng Y F, Chou F F, Lee T Y
Department of Surgery and Radiology, Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung Hsien, Taiwan, Republic of China.
Surgery. 1995 Jan;117(1):32-6. doi: 10.1016/s0039-6060(05)80226-0.
Hepatolithiasis with intrahepatic biliary strictures, more common in Southeast Asia than elsewhere, remains a difficult problem to manage. Hepatic resection has recently been advocated as one of the treatment modalities for hepatolithiasis; however, this procedure is not without risk. This study was designed to achieve complete clearance of the stones, eliminate bile stasis, and avoid the potential risks of hepatic resection in the patient with hepatolithiasis and intrahepatic biliary stricture.
In this prospective clinical trial 13 patients with retained left hepatolithiasis and intrahepatic biliary strictures were included. All the patients met the following criteria: (1) initial surgical procedure for hepatolithiasis, (2) normal gross findings of the left liver, and (3) no obvious clinical evidence of an associated intrahepatic cholangiocarcinoma. After the operation they underwent matured T-tube tract ductal dilatation with percutaneous transhepatic cholangioscopy tube stenting. Choledochoscopic electrohydraulic lithotripsy was used in five patients after dilatation when impacted or large stones were encountered.
Complete clearance of the stones was achieved in these 13 patients. One patient had fevers develop after ductal dilatation, and another patient had mild hemobilia after electrohydraulic lithotripsy. Both recovered uneventfully with conservative treatment. These successfully treated patients remain well, with a mean follow-up period of 20 months.
Postoperative matured T-tube tract ductal dilatation and stenting, combined with endoscopic electrohydraulic lithotripsy when indicated, is an effective and safe alternative to hepatic resection for selected left hepatolithiasis with intrahepatic biliary stricture.
肝内胆管结石合并肝内胆管狭窄在东南亚地区比其他地方更为常见,仍是一个难以处理的问题。肝切除术近来被提倡作为肝内胆管结石的治疗方式之一;然而,该手术并非没有风险。本研究旨在实现结石的完全清除,消除胆汁淤积,并避免肝内胆管结石合并肝内胆管狭窄患者肝切除的潜在风险。
在这项前瞻性临床试验中,纳入了13例左肝残留结石合并肝内胆管狭窄的患者。所有患者均符合以下标准:(1)肝内胆管结石初次手术;(2)左肝大体检查正常;(3)无肝内胆管癌相关的明显临床证据。术后,他们接受了成熟的经皮经肝胆管镜置管支架引流下的T管窦道扩张术。当遇到嵌顿或较大结石时,5例患者在扩张后采用了胆道镜下电液压碎石术。
这13例患者结石均完全清除。1例患者在胆管扩张后出现发热,另1例患者在电液压碎石术后出现轻度胆血反流。经保守治疗后,二者均顺利康复。这些成功治疗的患者情况良好,平均随访期为20个月。
对于选定的左肝肝内胆管结石合并肝内胆管狭窄患者,术后成熟的T管窦道扩张和支架置入术,必要时联合内镜下电液压碎石术,是一种有效且安全的肝切除术替代方案。