Sheen-Chen S M, Cheng Y F, Chen F C, Chou F F, Lee T Y
Department of Surgery and Diagnostic Radiology, Chang Gung Memorial Hospital, Kaohsiung, Chang Gung Medical College, Hsien, Taiwan.
Gut. 1998 May;42(5):708-10. doi: 10.1136/gut.42.5.708.
Hepatolithiasis is prevalent in south-east Asia and presents a difficult management problem. Intrahepatic strictures with or without awkward ductal angulation of the biliary tree are the main reasons for the reported high incidence of postoperative residual stones. Without proper treatment, biliary strictures and residual stones can lead to repeated episodes of cholangitis, liver abscess, secondary biliary cirrhosis, portal hypertension, and death from sepsis or hepatic failure. The purposes of our treatment strategy were to achieve complete clearance of the stones and relief of bile stasis.
From January 1991 to July 1992, 90 patients with residual postoperative hepatolithiasis and intrahepatic strictures were treated. Postoperative ductal dilatation with percutaneous transhepatic cholangioscopy tube stenting through a mature T tube tract was performed. Choledochoscopic electrohydraulic lithotripsy was applied when impacted or large stones were encountered.
Complete clearance of stones was achieved in 78 patients (87%). Mild haemobilia occurred in five patients (5.5%) and fever developed in seven patients (7.7%), and these patients recovered after conservative treatment. The rate of stone recurrence after a mean follow up of 43 months was 8%. Intrahepatic cholangiocarcinoma developed in one patient (1.1%).
Postoperative ductal dilatation and stenting, combined with endoscopic electrohydraulic lithotripsy when indicated, is an effective and safe treatment with a low recurrence rate for complicated residual hepatolithiasis with biliary stricture.
肝内胆管结石在东南亚地区较为常见,其治疗颇具难度。肝内胆管狭窄伴或不伴有胆管树的异常成角是术后残余结石发生率较高的主要原因。若未得到恰当治疗,胆管狭窄和残余结石可导致胆管炎反复发作、肝脓肿、继发性胆汁性肝硬化、门静脉高压,以及因败血症或肝衰竭而死亡。我们的治疗策略旨在实现结石的完全清除及胆汁淤积的缓解。
1991年1月至1992年7月,对90例术后残余肝内胆管结石合并肝内胆管狭窄的患者进行了治疗。通过成熟的T管窦道,采用经皮经肝胆管镜置管扩张术进行术后胆管扩张。遇到嵌顿性结石或较大结石时,应用胆管镜下液电碎石术。
78例患者(87%)实现了结石的完全清除。5例患者(5.5%)出现轻度胆道出血,7例患者(7.7%)出现发热,经保守治疗后这些患者均康复。平均随访43个月后,结石复发率为8%。1例患者(1.1%)发生了肝内胆管癌。
术后胆管扩张及支架置入,必要时联合内镜下液电碎石术,是治疗合并胆管狭窄的复杂性残余肝内胆管结石的一种有效且安全的方法,复发率低。