Shore D
Department of Microbiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032.
Trends Genet. 1994 Nov;10(11):408-12. doi: 10.1016/0168-9525(94)90058-2.
The yeast protein RAP1 is a sequence-specific DNA-binding protein that binds to many promoters, to two elements that silence mating-type genes, and to [(C)1-3A]n tracts at telomeres. RAP1 is essential for cell viability and can function as either an activator or a repressor of transcription, depending upon the context of its binding site. Recent experiments suggest that its function may be determined by different sets of protein-protein interactions at promoters and silencers. At the ends of chromosomes, RAP1 plays an important role in both silencing (telomere position effect) and telomere structure.
酵母蛋白RAP1是一种序列特异性DNA结合蛋白，它能与许多启动子、两个沉默交配型基因的元件以及端粒处的[(C)1-3A]n序列结合。RAP1对细胞活力至关重要，根据其结合位点的情况，它既可以作为转录激活因子，也可以作为转录抑制因子发挥作用。最近的实验表明，其功能可能由启动子和沉默子处不同的蛋白质-蛋白质相互作用组决定。在染色体末端，RAP1在沉默（端粒位置效应）和端粒结构方面都发挥着重要作用。
