比较研究：和中核糖体基因转录的调控机制。

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba 3-8-1, Tokyo 153-8902, Japan.

Universal Biology Institute, The University of Tokyo, Hongo 7-3-1, Tokyo 113-0033, Japan.

Biomolecules. 2023 Feb 3;13(2):288. doi: 10.3390/biom13020288.

Restricting ribosome biosynthesis and assembly in response to nutrient starvation is a universal phenomenon that enables cells to survive with limited intracellular resources. When cells experience starvation, nutrient signaling pathways, such as the target of rapamycin (TOR) and protein kinase A (PKA), become quiescent, leading to several transcription factors and histone modification enzymes cooperatively and rapidly repressing ribosomal genes. Fission yeast has factors for heterochromatin formation similar to mammalian cells, such as H3K9 methyltransferase and HP1 protein, which are absent in budding yeast. However, limited studies on heterochromatinization in ribosomal genes have been conducted on fission yeast. Herein, we shed light on and compare the regulatory mechanisms of ribosomal gene transcription in two species with the latest insights.

响应营养饥饿限制核糖体生物合成和组装是一种普遍现象，使细胞能够在有限的细胞内资源下存活。当细胞经历饥饿时，营养信号通路，如雷帕霉素靶蛋白 (TOR) 和蛋白激酶 A (PKA)，变得静止，导致几个转录因子和组蛋白修饰酶协同且快速地抑制核糖体基因。裂殖酵母具有类似于哺乳动物细胞的异染色质形成因子，如 H3K9 甲基转移酶和 HP1 蛋白，而在芽殖酵母中则不存在。然而，关于裂殖酵母中核糖体基因异染色质形成的研究还很有限。在此，我们根据最新的研究进展，阐明并比较了两种物种中核糖体基因转录的调控机制。