Lederman M M
Department of Medicine, University Hospitals of Cleveland, OH 44106.
Ann Intern Med. 1995 Feb 1;122(3):218-22. doi: 10.7326/0003-4819-122-3-199502010-00010.
This essay reviews the rationale underlying host-directed or immune-based therapeutic strategies for human immunodeficiency virus (HIV) infection and its complications. These approaches have seen only limited trial in the past 10 years, but as more is learned about the immunopathogenesis of HIV disease and as the limitations of virus-directed therapies become more apparent, the need to pursue other therapeutic avenues has become increasingly important. Moreover, properly designed trials of host-directed and immune-based therapies can provide key insights into the pathogenesis of HIV disease that may be otherwise unattainable through in vitro studies.
本文综述了针对人类免疫缺陷病毒（HIV）感染及其并发症的宿主导向或基于免疫的治疗策略的基本原理。在过去十年中，这些方法仅进行了有限的试验，但随着对HIV疾病免疫发病机制的了解越来越多，以及病毒导向疗法的局限性变得更加明显，寻求其他治疗途径的必要性变得越来越重要。此外，精心设计的宿主导向和基于免疫的疗法试验可以提供对HIV疾病发病机制的关键见解，而这些见解可能无法通过体外研究获得。
