一项关于简单恐惧症症状激发的正电子发射断层扫描研究。
A positron emission tomographic study of simple phobic symptom provocation.
作者信息
Rauch S L, Savage C R, Alpert N M, Miguel E C, Baer L, Breiter H C, Fischman A J, Manzo P A, Moretti C, Jenike M A
机构信息
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston.
出版信息
Arch Gen Psychiatry. 1995 Jan;52(1):20-8. doi: 10.1001/archpsyc.1995.03950130020003.
BACKGROUND
The goal of this study was to determine the mediating neuroanatomy of simple phobic symptoms.
METHODS
Positron emission tomography and oxygen 15 were used to measure normalized regional cerebral blood flow in seven subjects with simple phobia during control and provoked states. Stereotactic transformation and statistical parametric mapping techniques were employed to determine the locations of significant activation.
RESULTS
Statistical parametric maps demonstrated significant increases in normalized regional blood flow for the symptomatic state compared with the control state in the anterior cingulate cortex, the insular cortex, the anterior temporal cortex, the somatosensory cortex, the posterior medial orbitofrontal cortex, and the thalamus.
CONCLUSIONS
The results suggest that anxiety associated with the simple phobic symptomatic state is mediated by paralimbic structures. Moreover, activation of somatosensory cortex may reflect tactile imagery as one component of the phobic symptomatic condition.
背景
本研究的目的是确定单纯恐惧症症状的中介神经解剖结构。
方法
使用正电子发射断层扫描和氧15来测量7名患有单纯恐惧症的受试者在对照状态和激发状态下的标准化局部脑血流量。采用立体定向变换和统计参数映射技术来确定显著激活的位置。
结果
统计参数图显示，与对照状态相比，症状状态下前扣带回皮质、岛叶皮质、颞前皮质、体感皮质、眶额内侧后皮质和丘脑的标准化局部血流量显著增加。
结论
结果表明，与单纯恐惧症症状状态相关的焦虑由边缘旁结构介导。此外，体感皮质的激活可能反映了触觉意象，这是恐惧症状状态的一个组成部分。
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