大鼠海马中血管加压素V2受体mRNA存在的证据。
Evidence for the existence of vasopressin V2 receptor mRNA in rat hippocampus.
作者信息
Hirasawa A, Nakayama Y, Ishiharada N, Honda K, Saito R, Tsujimoto G, Takano Y, Kamiya H
机构信息
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.
出版信息
Biochem Biophys Res Commun. 1994 Dec 30;205(3):1702-6. doi: 10.1006/bbrc.1994.2864.
Arginine-vasopressin (AVP) in the septum and hippocampus are thought to be involved in memory and learning, and their receptors have been classified into three subtypes, V1a, V1b and V2. In this study, we tested for AVP V1a- and V2-receptor mRNAs in the hippocampus of adult rats by a reverse transcription-polymerase chain reaction (RT-PCR) method. PCR product of the V2 receptor mRNA was detected in the hippocampus, but that of V1a receptor mRNA was not. This is the first demonstration of the existence of the V2 receptor mRNA in the hippocampus.
中隔和海马体中的精氨酸加压素（AVP）被认为与记忆和学习有关，其受体已被分为三种亚型，即V1a、V1b和V2。在本研究中，我们采用逆转录-聚合酶链反应（RT-PCR）方法检测成年大鼠海马体中AVP V1a和V2受体的mRNA。在海马体中检测到了V2受体mRNA的PCR产物，但未检测到V1a受体mRNA的PCR产物。这是首次证明海马体中存在V2受体mRNA。
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