Catrina S B, Rotarus R, Wivall I-L, Coculescu M, Brismar K
Department of Endocrinology, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania.
J Endocrinol Invest. 2004 Jan;27(1):47-51. doi: 10.1007/BF03350910.
Melatonin secretion is modulated by the light-dark schedule, mainly through a sympathetic input to the pineal gland. Besides this, arginine vasopressin (AVP) has been found in the pineal glands of several animal species and there is experimental evidence that AVP modulates melatonin secretion in animals. However, the interaction between vasopressin and melatonin secretion in humans has not been systematically investigated. We proposed to study the nocturnal melatonin pattern in patients with central diabetes insipidus (CDI) who lack endogenous secretion of AVP, and the effect on their melatonin secretion of the agonist for V2 type receptors: desmopressin (1-Desamino [8-D Arginine] vasopressin). Plasma melatonin levels were measured in 14 patients with CDI, every 2 h starting from 22:00 h until 06:00 h, following iv injection of saline (day 1) and 3 microg desmopressin (day 2) at 20:00 h. The lights were turned off at 22:30 h and the samples were taken in a dim light. The plasma melatonin secretion pattern was normal in patients with CDI. Desmopressin at a dose 3 times higher than the antidiuretic one did not modify the melatonin levels or the time of the peak secretion. In conclusion melatonin secretion is not modulated by AVP in humans.
褪黑素的分泌受明暗周期调节，主要通过交感神经对松果体的输入来实现。除此之外，在几种动物的松果体中发现了精氨酸加压素（AVP），并且有实验证据表明AVP可调节动物的褪黑素分泌。然而，血管加压素与人类褪黑素分泌之间的相互作用尚未得到系统研究。我们提议研究中枢性尿崩症（CDI）患者的夜间褪黑素模式，这些患者缺乏内源性AVP分泌，以及V2型受体激动剂去氨加压素（1-去氨基[8-D-精氨酸]血管加压素）对其褪黑素分泌的影响。在14例CDI患者中，从22:00开始每2小时测量一次血浆褪黑素水平，直至06:00，在20:00静脉注射生理盐水（第1天）和3微克去氨加压素（第2天）。22:30关灯，在昏暗灯光下采集样本。CDI患者的血浆褪黑素分泌模式正常。比抗利尿剂量高3倍的去氨加压素并未改变褪黑素水平或分泌高峰时间。总之，在人类中，褪黑素分泌不受AVP调节。
