Fell J T
Department of Pharmacy, University of Manchester, UK.
J Anat. 1996 Dec;189 ( Pt 3)(Pt 3):517-9.
Particle uptake and translocation occur at specific sites in the gastrointestinal tract. Several drugs are also absorbed from solution only through narrow "windows' in the small intestine. In these circumstances, optimum therapeutic benefit would be obtained if the active agent was targeted to the appropriate site in the gastrointestinal tract. Targeting relies on exploiting a unique feature of the intended site and protecting the active agent until it reaches that site. This minireview highlights the problems in achieving site specificity in the gastrointestinal tract and examines possible solutions to the problem for 2 regions, the stomach and the colon.
颗粒摄取和转运发生在胃肠道的特定部位。几种药物也仅通过小肠中的狭窄“窗口”从溶液中吸收。在这些情况下，如果活性剂靶向胃肠道中的适当部位，将获得最佳治疗效果。靶向依赖于利用目标部位的独特特征，并在活性剂到达该部位之前对其进行保护。这篇综述强调了在胃肠道中实现位点特异性所面临的问题，并探讨了针对胃和结肠这两个区域该问题的可能解决方案。
