叶酸状态与结肠腺瘤性息肉。一项结肠镜检查对照研究。

Folate status and adenomatous colonic polyps. A colonoscopically controlled study.

作者信息

Paspatis G A, Kalafatis E, Oros L, Xourgias V, Koutsioumpa P, Karamanolis D G

机构信息

Gastroenterology Department, Tzanion General Hospital, Piraeus, Greece.

出版信息

Dis Colon Rectum. 1995 Jan;38(1):64-7; discussion 67-8. doi: 10.1007/BF02053860.

DOI:10.1007/BF02053860

PMID:7813348

Abstract

PURPOSE

The aim of our study was to assess any association of folate with development of colonic adenomas.

METHODS

Serum and red blood cell folate levels were measured in 62 colonoscopically and histologically evaluated patients with colon adenomas (Group A) and in 50 selected colonoscopically negative controls (Group B). Patients with colon polyps underwent colonoscopy for alterations of bowel habits or abdominal pain, and detected polyps were found coincidentally. Controls underwent colonoscopy for alterations of bowel habits or abdominal pain. There was no difference in hematocrit between the two groups.

RESULTS

The mean serum folate level in patients with colonic adenomas was 4.57 ng/ml +/- 2.8 standard deviations (SD), and the mean red blood cells folate levels were 536 ng/ml +/- 273.3 (SD). In controls the mean folate levels in serum and red blood cells were 5.09 ng/ml +/- 2.7 (SD) and 743.8 ng/ml +/- 297.1 (SD), respectively. The red blood cell folate level of colon adenoma patients was statistically lower than the respective level of controls at a highly significant level (P < 0.01).

CONCLUSIONS

We suggest that depressed red blood cell folate levels are associated with development of colonic adenomas.

摘要

目的

我们研究的目的是评估叶酸与结肠腺瘤发生之间的任何关联。

方法

对62例经结肠镜检查和组织学评估的结肠腺瘤患者（A组）以及50例经结肠镜检查选定的阴性对照者（B组）测定血清和红细胞叶酸水平。结肠息肉患者因排便习惯改变或腹痛接受结肠镜检查，所发现的息肉为偶然发现。对照者因排便习惯改变或腹痛接受结肠镜检查。两组间血细胞比容无差异。

结果

结肠腺瘤患者的平均血清叶酸水平为4.57 ng/ml±2.8标准差（SD），平均红细胞叶酸水平为536 ng/ml±273.3（SD）。对照组血清和红细胞中的平均叶酸水平分别为5.09 ng/ml±2.7（SD）和743.8 ng/ml±297.1（SD）。结肠腺瘤患者的红细胞叶酸水平显著低于对照组相应水平（P < 0.01）。