Klingensmith J, Nusse R
Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, California 94305.
Dev Biol. 1994 Dec;166(2):396-414. doi: 10.1006/dbio.1994.1325.
Wingless, a member of the Wnt gene family, is an essential gene for segmentation in Drosophila, and is also involved in many other patterning events. The gene encodes a secreted protein that can regulate gene expression in adjacent cells. Recently, significant progress has been made in elucidating the signal transduction pathway of wingless, mainly by genetic experiments but increasingly also at the biochemical level. While many components of wingless signaling, in particular a receptor, remain to be identified, our current understanding of wingless pathway is more advanced than that of other Wnt genes. We will give an overview of the various roles of wingless in development, and we will then summarize the wingless signaling pathway as it has emerged from genetic and biochemical studies. Where appropriate, wingless signaling will be compared to the activity of vertebrate Wnt proteins.
无翅蛋白是Wnt基因家族的成员之一，是果蝇体节形成所必需的基因，还参与许多其他的模式形成事件。该基因编码一种分泌蛋白，可调节相邻细胞中的基因表达。最近，在阐明无翅蛋白的信号转导途径方面取得了重大进展，主要是通过遗传学实验，但在生化水平上的研究也越来越多。虽然无翅蛋白信号传导的许多成分，特别是一种受体，仍有待确定，但我们目前对无翅蛋白途径的理解比其他Wnt基因更为深入。我们将概述无翅蛋白在发育中的各种作用，然后总结从遗传学和生化研究中得出的无翅蛋白信号转导途径。在适当的情况下，将无翅蛋白信号传导与脊椎动物Wnt蛋白的活性进行比较。
