果蝇中卷曲蛋白家族的一个新成员作为无翅蛋白受体发挥作用。
A new member of the frizzled family from Drosophila functions as a Wingless receptor.
作者信息
Bhanot P, Brink M, Samos C H, Hsieh J C, Wang Y, Macke J P, Andrew D, Nathans J, Nusse R
机构信息
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
出版信息
Nature. 1996 Jul 18;382(6588):225-30. doi: 10.1038/382225a0.
Receptors for Wingless and other signalling molecules of the Wnt gene family have yet to be identified. We show here that cultured Drosophila cells transfected with a novel member of the frizzled gene family in Drosophila, Dfz2, respond to added Wingless protein by elevating the level of the Armadillo protein. Moreover, Wingless binds to Drosophila or human cells expressing Dfz2. These data demonstrate that Dfz2 functions as a Wingless receptor, and they imply, in general, that Frizzled proteins are receptors for the Wnt signalling molecules.
无翅基因（Wingless）以及Wnt基因家族的其他信号分子的受体尚未被鉴定出来。我们在此表明，用果蝇卷曲基因家族（frizzled gene family）的一个新成员Dfz2转染的培养果蝇细胞，会通过提高犰狳蛋白（Armadillo protein）的水平来响应添加的无翅蛋白。此外，无翅蛋白能与表达Dfz2的果蝇或人类细胞结合。这些数据证明Dfz2作为无翅蛋白的受体发挥作用，并且总体上意味着卷曲蛋白（Frizzled proteins）是Wnt信号分子的受体。
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