Yamasaki M, Nakamura H, Kameyama Y
Department of Endodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Japan.
Int Endod J. 1994 Sep;27(5):245-51. doi: 10.1111/j.1365-2591.1994.tb00263.x.
A study was carried out to investigate the effect of formocresol (formalin-creosote) on the periapical tissue after pulpectomy in rats. A pulpectomy was performed on the mesial root of the right mandibular first molar, and, in group A, a paper point containing saline was inserted into the root canal. In group B, a paper point containing formocresol was inserted, and in group C, a drop of formocresol was applied and a paper point containing formocresol was inserted into the root canal. The periapical tissue was examined histologically and histometrically at 3, 7, 14, and 28 days after insertion, and the inflammatory cells and fibroblasts in the apical granulation tissue were also counted. Histologically, in group A, the inflammation observed was slight at 14 and 28 days, while in groups B and C, a moderate inflammation remained. Histometrically, the area of the apical periodontal ligament in groups B and C was increased significantly compared with that in group A at 14 and 28 days. The inflammatory cell count in groups B and C increased significantly compared with that in group A at 7, 14, and 28 days, whereas the fibroblast count in Groups B and C decreased compared with that in Group A at 7, 14, and 28 days. These results demonstrate that formocresol delayed the healing of periapical tissue after pulpectomy.
开展了一项研究，以调查甲醛甲酚（甲醛 - 木馏油）对大鼠牙髓摘除术后根尖周组织的影响。对右侧下颌第一磨牙的近中根进行牙髓摘除术，在A组中，将含生理盐水的纸尖插入根管。在B组中，插入含甲醛甲酚的纸尖，在C组中，滴加一滴甲醛甲酚并将含甲醛甲酚的纸尖插入根管。在插入后3、7、14和28天对根尖周组织进行组织学和组织计量学检查，并对根尖肉芽组织中的炎性细胞和成纤维细胞进行计数。组织学上，在A组中，14天和28天时观察到的炎症轻微，而在B组和C组中，炎症持续存在且程度中等。组织计量学上，在14天和28天时，B组和C组的根尖牙周膜面积与A组相比显著增加。在7、14和28天时，B组和C组的炎性细胞计数与A组相比显著增加，而在7、14和28天时，B组和C组的成纤维细胞计数与A组相比减少。这些结果表明，甲醛甲酚延迟了牙髓摘除术后根尖周组织的愈合。
