Hojo S, Komatsu M, Okuda R, Takahashi N, Yamada T
Department of Oral Biochemistry, Tohoku University School of Dentistry, Sendai, Japan.
J Dent Res. 1994 Dec;73(12):1853-7. doi: 10.1177/00220345940730121001.
Organic acids in caries lesions play important roles in initiation and progress of dental caries. We investigated relationships between clinical types of dentin caries and acid profile or pH in the lesions. Caries lesions in dentin from 76 permanent teeth were classified into active, arrested, situated beneath a restoration, and unclassified types. The pH of carious dentin was distinctly lower than that of sound dentin (p < 0.001). Carious dentin with a high percentage of lactate had a lower pH than that with a high percentage of acetate and propionate (p < 0.001). Dentin from active lesions showed a mean pH of 4.9, and the dominant acid was lactate (mean percentage, 88.2). In contrast, carious dentin from arrested lesions showed a higher pH, 5.7, with acetate and propionate as the dominant acids (mean percentages of acetate and propionate, 64.0 and 18.2, respectively). The acid profile (mean percentages of acetate and propionate, 54.0 and 27.7, respectively) and pH (mean 5.8) of carious dentin sampled from lesions beneath a restoration were similar to those of dentin from arrested lesions. This study showed a clear relationship between clinical classification of dentin caries and acid profile and pH, suggesting that both factors are important in dentin caries etiology.
龋损中的有机酸在龋齿的发生和发展过程中起着重要作用。我们研究了牙本质龋临床类型与龋损中酸谱或pH值之间的关系。将76颗恒牙牙本质中的龋损分为活动型、静止型、修复体下方型和未分类型。龋坏牙本质的pH值明显低于健康牙本质（p < 0.001）。乳酸含量高的龋坏牙本质的pH值低于乙酸和丙酸含量高的龋坏牙本质（p < 0.001）。活动型龋损的牙本质平均pH值为4.9，主要酸为乳酸（平均百分比为88.2）。相比之下，静止型龋损的龋坏牙本质pH值较高，为5.7，主要酸为乙酸和丙酸（乙酸和丙酸的平均百分比分别为64.0和18.2）。从修复体下方龋损中取样的龋坏牙本质的酸谱（乙酸和丙酸的平均百分比分别为54.0和27.7）和pH值（平均5.8）与静止型龋损的牙本质相似。本研究表明牙本质龋的临床分类与酸谱和pH值之间存在明确关系，表明这两个因素在牙本质龋病因学中都很重要。
