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Facial morphometry of Ecuadorian patients with growth hormone receptor deficiency/Laron syndrome.

作者信息

Schaefer G B, Rosenbloom A L, Guevara-Aguirre J, Campbell E A, Ullrich F, Patil K, Frias J L

机构信息

Department of Pediatrics, University of Nebraska Medical Center, Omaha 68198-5430.

出版信息

J Med Genet. 1994 Aug;31(8):635-9. doi: 10.1136/jmg.31.8.635.

DOI:10.1136/jmg.31.8.635
PMID:7815422
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1050027/
Abstract

Facial morphometry using computerised image analysis was performed on patients with growth hormone receptor deficiency (Laron syndrome) from an inbred population of southern Ecuador. Morphometrics were compared for 49 patients, 70 unaffected relatives, and 14 unrelated persons. Patients with growth hormone receptor deficiency showed significant decreases in measures of vertical facial growth as compared to unaffected relatives and unrelated persons with short stature from other causes. This report validates and quantifies the clinical impression of foreshortened facies in growth hormone receptor deficiency.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfff/1050027/36ac6a0a050a/jmedgene00287-0057-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfff/1050027/0c3469d15fc2/jmedgene00287-0056-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfff/1050027/36ac6a0a050a/jmedgene00287-0057-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfff/1050027/0c3469d15fc2/jmedgene00287-0056-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfff/1050027/36ac6a0a050a/jmedgene00287-0057-a.jpg

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本文引用的文献

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Anthropometric and anthroposcopic findings of the nasal and facial region in cleft patients before and after primary lip and palate repair.唇腭裂患者在一期唇腭裂修复术前及术后鼻面部区域的人体测量学和视诊检查结果。
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Growth hormone receptor deficiency in Ecuador: clinical and biochemical phenotype in two populations.厄瓜多尔的生长激素受体缺乏症：两个群体的临床和生化表型
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Facial asymmetry in healthy North American Caucasians. An anthropometrical study.
生长激素受体基因变异与三维下颌形态
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Model of pediatric pituitary hormone deficiency separates the endocrine and neural functions of the LHX3 transcription factor in vivo.儿童垂体激素缺乏症模型在体内分离了 LHX3 转录因子的内分泌和神经功能。
Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):173-8. doi: 10.1073/pnas.1009501108. Epub 2010 Dec 13.
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Laron's syndrome in two siblings.两兄弟患拉伦综合征。
Indian J Pediatr. 2007 Sep;74(9):870-1. doi: 10.1007/s12098-007-0159-y.
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Endocrine. 2000 Apr;12(2):107-19. doi: 10.1385/ENDO:12:2:107.
Angle Orthod. 1981 Jan;51(1):70-7. doi: 10.1043/0003-3219(1981)051<0070:FAIHNA>2.0.CO;2.
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