Farkas L G, Kolar J C, Munro I R
Cleft Palate J. 1985 Oct;22(4):253-65.
Twenty craniofacial indices composed of 26 surface measurements taken directly from the head and face were determined in 14 Apert's syndrome patients 18 days to 5 years old (younger subgroup) and 14 patients ages 6 years to 15 years old (older subgroup). All of the patients were North American Caucasians who had undergone early suture release but no facial repair. The indices were compared with those in healthy controls of the same age and sex. The wide intercanthal distance in relation to the narrow soft nose was the most frequent (81.5%) and extensive (17.7% above the maximum normal index value) disproportion. Abnormal indices occurred most often with the combination of one abnormal and one normal measurement (61.0%). All seven of the 16 disproportions seen in both age subgroups increased in frequency nonsignificantly with age: the supernormal cephalic, intercanthal, nasal, and vertical mandibulofacial indices and the subnormal nasofacial, upper face, and jaws' arcs indices. Of the six disproportions that decreased in frequency with age, four changed significantly (the supernormal frontoparietal and frontozygomatic indices and the subnormal mandibulofacial and nasozygomatic indices) and two changed nonsignificantly (the supernormal intercanthoalar and subnormal cheilozygomatic indices). With the exception of two nasal proportions, the extent of the disproportionality decreased in all of the indices that increased with age.
在14例年龄为18天至5岁的Apert综合征患儿（较小组）和14例年龄为6岁至15岁的患儿（较大组）中，测定了20个颅面指数，这些指数由直接取自头部和面部的26项体表测量值组成。所有患者均为北美白种人，均接受了早期缝线松解，但未进行面部修复。将这些指数与相同年龄和性别的健康对照者的指数进行比较。内眦间距宽而软鼻窄是最常见（81.5%）且差异最大（比最大正常指数值高17.7%）的比例失调情况。异常指数最常出现在一项异常测量值与一项正常测量值同时出现的组合中（61.0%）。在两个年龄组中均观察到的16种比例失调情况中，有7种随年龄增长频率非显著性增加：头指数、内眦指数、鼻指数、垂直下颌面指数超常，以及鼻面指数、上面指数和颌弓指数低于正常。在随年龄增长频率降低的6种比例失调情况中，有4种变化显著（额顶指数和额颧指数超常，下颌面指数和鼻颧指数低于正常），2种变化不显著（内眦翼指数超常和唇颧指数低于正常）。除了两种鼻比例失调情况外，在所有随年龄增长的指数中，比例失调的程度均降低。
