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猿猴免疫缺陷病毒SIVmac嵌合病毒，其env基因来源于感染SIV后引发脑炎的脑部，具有巨噬细胞嗜性，但无神经毒性。

Simian immunodeficiency virus SIVmac chimeric virus whose env gene was derived from SIV-encephalitic brain is macrophage-tropic but not neurovirulent.

作者信息

Joag S V, Stephens E B, Galbreath D, Zhu G W, Li Z, Foresman L, Zhao L J, Pinson D M, Narayan O

机构信息

Marion Merrell Dow Laboratory of Viral Pathogenesis, Department of Microbiology, University of Kansas Medical Center, Kansas City 66160-7424.

出版信息

J Virol. 1995 Feb;69(2):1367-9. doi: 10.1128/JVI.69.2.1367-1369.1995.

DOI:10.1128/JVI.69.2.1367-1369.1995
PMID:7815523
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC188722/
Abstract

We inoculated four rhesus macaques with molecularly cloned simian immunodeficiency virus SIVmac239/17E env, a chimeric virus whose env gene was derived from the brain of an SIV-encephalitic macaque. Blood and lymphoid tissues had high frequencies of infected cells. The virus was neuroinvasive, but productive virus replication did not occur in the brain, and animals did not develop encephalitis.

摘要

我们用分子克隆的猿猴免疫缺陷病毒SIVmac239/17E env接种了4只恒河猴，该嵌合病毒的env基因来源于一只患SIV脑炎猕猴的大脑。血液和淋巴组织中感染细胞的频率很高。该病毒具有神经侵袭性，但在大脑中未发生有 productive virus replication（可能是“有效病毒复制”，此处不太明确该专业术语准确表述），且动物未发生脑炎。

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Simian immunodeficiency virus SIVmac chimeric virus whose env gene was derived from SIV-encephalitic brain is macrophage-tropic but not neurovirulent.猿猴免疫缺陷病毒SIVmac嵌合病毒，其env基因来源于感染SIV后引发脑炎的脑部，具有巨噬细胞嗜性，但无神经毒性。
J Virol. 1995 Feb;69(2):1367-9. doi: 10.1128/JVI.69.2.1367-1369.1995.
2
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