Yusa T, Nohara A, Matayoshi K, Zukeran H
Department of Anesthesiology, Faculty of Medicine, University Hospital, University of the Ryukyus, Okinawa.
Masui. 1994 Oct;43(10):1486-92.
The effect of intraoperative stored blood transfusion on the changes in plasma neutrophil elastase (PMN-E) was studied in packed red cell, and in the patients transfused with stored blood (400-1000 ml) during surgery (n = 22), compared with the control in patients who had not received transfusion (n = 6). PMN-E was measured as elastase.alpha 1-antitrypsin complex (EAC) and the effect of ulinastatin (UTI) treatment on EAC was also evaluated. There was a significant correlation between transfusion volume and EAC or EAC/WBC (r2 = 0.65, P < 0.05 and r2 = 0.51, P < 0.05; respectively). There was no significant correlation between transfusion volume and EAC (r2 = 0.44, P > 0.05) in patients with UTI treatment during blood transfusion. These results and increased H2O2 concentration of expired breath in the patient whose plasma EAC exceeded 1,000 micrograms.l-1, suggested PMN-E is released from triggered neutrophil by increased EAC.
研究了术中输注库存血对浓缩红细胞中血浆中性粒细胞弹性蛋白酶（PMN-E）变化的影响，并在手术期间输注库存血（400-1000毫升）的患者（n = 22）中进行了研究，与未接受输血的患者对照组（n = 6）进行比较。PMN-E以弹性蛋白酶-α1-抗胰蛋白酶复合物（EAC）进行测量，并评估了乌司他丁（UTI）治疗对EAC的影响。输血量与EAC或EAC/白细胞之间存在显著相关性（r2 = 0.65，P < 0.05和r2 = 0.51，P < 0.05；分别）。在输血期间接受UTI治疗的患者中，输血量与EAC之间无显著相关性（r2 = 0.44，P > 0.05）。这些结果以及血浆EAC超过1000微克·升-1的患者呼出气体中H2O2浓度升高，提示PMN-E是由EAC增加触发的中性粒细胞释放的。
