Fournie J W, Vogelbein W K
U.S. Environmental Protection Agency, Center for Marine and Estuarine Disease Research, Gulf Breeze, Florida 32561.
Toxicol Pathol. 1994 May-Jun;22(3):237-47. doi: 10.1177/019262339402200302.
A high prevalence of exocrine pancreatic neoplasms occurred in mummichog, Fundulus heteroclitus, from a creosote-contaminated site in the Elizabeth River, Virginia. A total of 20 neoplasms were found in a group of about 1,300 fish obtained at this site over a 2-yr period. Of 240 fish collected during October 1991, 3.3% had pancreatic neoplasms. Adjusted total lesion prevalence for large adult fish (Size Class III: total length = 75-85 mm; Size Class IV: total length > 85 mm) was 6.7%. Pancreatic neoplasms were not observed in 234 fish collected at this site during May 1991, nor were they found in 420 fish obtained during fall 1991 from 1 uncontaminated and 6 moderately contaminated localities. Lesions involved both mesenteric and intrahepatic exocrine pancreas and ranged from well-differentiated acinar cell adenomas to poorly differentiated acinar cell carcinomas. One fish had an atypical acinar cell focus. All specimens with pancreatic neoplasms also had hepatocellular lesions. This epizootic of exocrine pancreatic neoplasia is the first to be reported in a wild fish population. Based on chemical characterization of the site and limited experimental data on chemically induced pancreatic carcinogenesis in other small fish species, the neoplasms were probably caused by exposure of the mummichog to chemical carcinogens in their environment.
在弗吉尼亚州伊丽莎白河一处受杂酚油污染的地点采集的底鳉（Fundulus heteroclitus）中，外分泌性胰腺肿瘤的患病率很高。在两年时间里，从该地点采集的约1300条鱼中总共发现了20个肿瘤。1991年10月采集的240条鱼中，3.3%患有胰腺肿瘤。大型成年鱼（III类：全长75 - 85毫米；IV类：全长> 85毫米）的调整后总病变患病率为6.7%。1991年5月在该地点采集的234条鱼中未观察到胰腺肿瘤，1991年秋季从1个未受污染和6个中度污染地点采集的420条鱼中也未发现胰腺肿瘤。病变累及肠系膜和肝内的外分泌胰腺，范围从高分化的腺泡细胞腺瘤到低分化的腺泡细胞癌。有一条鱼有一个非典型腺泡细胞病灶。所有患有胰腺肿瘤的标本也都有肝细胞病变。这种外分泌性胰腺肿瘤的 epizootic 是首次在野生鱼类种群中报道。根据该地点的化学特征以及其他小型鱼类化学诱导胰腺癌发生的有限实验数据，这些肿瘤可能是底鳉接触其环境中的化学致癌物所致。
