Kantelip J P, Patay M, Levy P, Mougin F, Didier J M
Laboratoire de Pharmacologie, Faculté de Médecine, CHRU, Besançon.
Therapie. 1994 Mar-Apr;49(2):107-12.
The consequences of sleep deprivation on vigilance and mood were evaluated in six healthy medical students the day after being on night duty and the following day, after recovering from a full night's sleep. Diurnal vigilance was studied using the Multiple Sleep Latency Test (MSLT) and mood was assessed on an anxiety self-evaluation scale. The study was conducted by means of a double-blind randomized trial to measure the effects of benzodiazepine (lormetazepam, 2 mg) compared to a placebo administered before the night recovery/full night's sleep. Sleep deprivation induced a significant decrease in vigilance the day following the night duty. Sleep latencies were shortened during the morning following the night of recovery/full night's sleep. The values obtained after administering the lormetazepam did not differ significantly from those obtained after administering the placebo. There were no considerable differences in the anxiety evaluation scores before and after the night of recovery/full night's sleep between the two sequences of the trial. This study suggests that a significant lack of sleep (a 36-hour sleep deficit) modifies diurnal vigilance over two nyctohemeral periods. Administration of benzodiazepine with a short half-life after occasional sleep deprivation does not change the reorganization of the sleep-waking cycle.
在六名健康医学生值夜班后的第二天以及经过一夜充足睡眠恢复后的第二天，对睡眠剥夺对警觉性和情绪的影响进行了评估。使用多次睡眠潜伏期试验（MSLT）研究日间警觉性，并通过焦虑自评量表评估情绪。该研究通过双盲随机试验进行，以测量与在夜间恢复/一夜充足睡眠前服用的安慰剂相比，苯二氮䓬类药物（氯美扎酮，2毫克）的效果。值夜班后的第二天，睡眠剥夺导致警觉性显著下降。在恢复/一夜充足睡眠后的早晨，睡眠潜伏期缩短。服用氯美扎酮后获得的值与服用安慰剂后获得的值没有显著差异。在试验的两个序列中，恢复/一夜充足睡眠前后的焦虑评估得分没有显著差异。这项研究表明，严重睡眠不足（36小时的睡眠 deficit）会在两个昼夜周期内改变日间警觉性。偶尔睡眠剥夺后服用半衰期短的苯二氮䓬类药物不会改变睡眠-觉醒周期的重新组织。
