Grønbaek M N, Deis A, Sørensen T I, Becker U, Borch-Johnsen K, Müller C F, Schnohr P, Jensen G
Københavns Sundhedsvaesen, Institut for Sygdomsforebyggelse.
Ugeskr Laeger. 1994 Nov 28;156(48):7214-8.
The aim of the study was to examine the association between self-reported alcohol intake and subsequent mortality from all causes, and to examine if the effect of alcohol intake on the risk of death was modified by sex, age, body mass index, and smoking habits. In a prospective population study of 7,234 women and 6,051 men aged 30-79 years alcohol- and tobacco consumption and body mass index were assessed in the period 1976-1978, and the population was followed until 1.1.1988 for mortality. A U-shaped curve described the relation between alcohol intake and mortality. The nadir of the risk function was observed at one to six beverages per week (relative risk set at 1.00). Abstainers had a relative risk of 1.37 (95% confidence intervals: 1.20-1.56), whereas those drinking more than 70 beverages per week had a relative risk of 2.29 (1.75-3.00). Among the drinkers, the risk was significantly higher than 1 only among those drinking more than 42 beverages per week. Neither sex, age, body mass index, nor smoking significantly modified the risk function. Our findings suggest that simple messages about the benefits of total abstinence may not be appropriate.
该研究的目的是检验自我报告的酒精摄入量与随后各种原因导致的死亡率之间的关联，并检验酒精摄入量对死亡风险的影响是否因性别、年龄、体重指数和吸烟习惯而有所改变。在一项对7234名年龄在30 - 79岁的女性和6051名男性进行的前瞻性人群研究中，在1976 - 1978年期间评估了酒精和烟草消费以及体重指数，并对该人群进行随访直至1988年1月1日以了解死亡率情况。一条U形曲线描述了酒精摄入量与死亡率之间的关系。风险函数的最低点出现在每周饮用1至6杯酒时（相对风险设定为1.00）。戒酒者相对风险为1.37（95%置信区间：1.20 - 1.56），而每周饮酒超过70杯的人相对风险为2.29（1.75 - 3.00）。在饮酒者中，只有每周饮酒超过42杯的人的风险显著高于1。性别、年龄、体重指数和吸烟均未显著改变风险函数。我们的研究结果表明，关于完全戒酒有益的简单信息可能并不合适。
