Grønbaek M N, Becker P U, Johansen D, Gottschau A, Schnohr P, Hein H O, Jensen G B, Sørensen T I
H:S Kommunehospitalet, Hovedstadens Center for Prospektive Befolkningsstudier, og Center for Epidemiologisk Grundforskning ved Institut for Sygdomsforebyggelse.
Ugeskr Laeger. 2001 May 21;163(21):2946-9.
The aim of the present population-based cohort study was to examine the association between alcohol intake and mortality from all causes, coronary heart disease, and cancer.
A prospective population study with baseline assessment of beer, wine and spirit consumption, smoking habits, educational level, physical activity, and body mass index in a total of 257,859 person-years follow-up on mortality.
A total of 4833 participants died, 1075 of these from coronary heart disease and 1552 of cancer. Compared with non-drinkers, light drinkers, who avoided wine, had a relative risk of death from all causes of 0.90 (0.82-0.99) and those who drank wine had a relative risk of 0.66 (0.55-0.77). Heavy drinkers, who avoided wine, were at higher risk of death from all causes than were heavy drinkers, who included wine in their alcohol consumption. Wine drinkers had a significantly lower mortality from both coronary heart disease and cancer than had non-wine drinkers (p = 0.007 and p = 0.004, respectively).
A moderate consumption of wine may have a beneficial effect on all causes of mortality, which is additive to that of alcohol. This effect may be attributable to a reduction in death from both coronary heart disease and cancer.
本基于人群的队列研究旨在探讨酒精摄入量与全因死亡率、冠心病死亡率和癌症死亡率之间的关联。
一项前瞻性人群研究，对啤酒、葡萄酒和烈酒消费量、吸烟习惯、教育水平、身体活动以及体重指数进行基线评估，对总计257,859人年进行死亡率随访。
共有4833名参与者死亡，其中1075人死于冠心病，1552人死于癌症。与不饮酒者相比，不喝葡萄酒的轻度饮酒者全因死亡的相对风险为0.90（0.82 - 0.99），而喝葡萄酒的轻度饮酒者全因死亡的相对风险为0.66（0.55 - 0.77）。不喝葡萄酒的重度饮酒者全因死亡风险高于饮酒中包含葡萄酒的重度饮酒者。喝葡萄酒者冠心病和癌症死亡率均显著低于不喝葡萄酒者（分别为p = 0.007和p = 0.004）。
适度饮用葡萄酒可能对全因死亡率产生有益影响，这是酒精有益影响之外的额外作用。这种影响可能归因于冠心病和癌症死亡率的降低。
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