Jocham D
Klinik für Urologie, Medizinischen Universität zu Lübeck.
Urologe A. 1994 Nov;33(6):547-52.
Photodynamic therapy (PDT) has been demonstrated to be an effective therapy for carcinoma in situ of the urinary bladder. The data recorded in the various pilot studies are not comparable, because different photosensitizers, various irradiation modalities and different doses of photosensitizers have been used. Present activities include basic research on principles of action of PDT, the development of photosensitizers with better tumor selectivity, optimization of irradiation modalities, and prospective randomized clinical trials, e.g. in superficial bladder cancer. Photodynamic fluorescence diagnosis (PDD) can be performed easily in clinical conditions with the use of the topically applicable fluorescent marker delta amino levulinic acid (ALA). There is a need for controlled clinical trials to check the efficacy suggested for PDD by the very promising data yielded by pilot studies.
光动力疗法（PDT）已被证明是治疗膀胱原位癌的有效方法。各项初步研究记录的数据不可比，因为使用了不同的光敏剂、多种照射方式以及不同剂量的光敏剂。目前的工作包括对光动力疗法作用原理的基础研究、开发具有更好肿瘤选择性的光敏剂、优化照射方式以及前瞻性随机临床试验，如针对浅表性膀胱癌的试验。使用局部适用的荧光标记物δ-氨基乙酰丙酸（ALA），光动力荧光诊断（PDD）在临床条件下易于进行。需要进行对照临床试验，以检验初步研究得出的非常有前景的数据所表明的PDD的疗效。
