Hashimoto Y, Matsuo S, Iizuka H
Department of Dermatology, Asahikawa Medical College, Japan.
Acta Derm Venereol. 1994 Sep;74(5):358-60. doi: 10.2340/0001555574359360.
DNA-flow cytometric analyses were performed on paraffin-embedded sections of trichilemmal carcinoma, proliferating trichilemmal cyst, and trichilemmal cyst. Nine out of 10 cases of trichilemmal carcinoma and 2 out of 5 cases of proliferating trichilemmal cyst showed aneuploidy. No aneuploidy was detected in 6 cases of benign trichilemmal cyst. The proliferating index (percentage of cells that exceeded the diploid peak (G0/G1) plus 4 standard deviations) of trichilemmal carcinoma, proliferating trichilemmal cyst, and trichilemmal cysts was 43.5 +/- 3.8%, 32.5 +/- 7.5%, and 23.1 +/- 2.0%, respectively. In one out of the 6 cases of trichilemmal carcinoma that were large enough for us to investigate regional differences, DNA ploidy heterogeneity was detected. The incidence of aneuploidy of trichilemmal carcinoma was significantly higher than that of squamous cell carcinoma (14%), previously described by us using the same method.
对毛发上皮癌、增殖性毛发囊肿和毛发囊肿的石蜡包埋切片进行了DNA流式细胞术分析。10例毛发上皮癌中有9例，5例增殖性毛发囊肿中有2例显示非整倍体。6例良性毛发囊肿未检测到非整倍体。毛发上皮癌、增殖性毛发囊肿和毛发囊肿的增殖指数（超过二倍体峰（G0/G1）加4个标准差的细胞百分比）分别为43.5±3.8%、32.5±7.5%和23.1±2.0%。在6例足够大以便我们研究区域差异的毛发上皮癌病例中，有1例检测到DNA倍体异质性。毛发上皮癌的非整倍体发生率显著高于我们之前使用相同方法描述的鳞状细胞癌（14%）。
