Holman B L
Semin Nucl Med. 1976 Jul;6(3):233-51. doi: 10.1016/s0001-2998(76)80007-4.
Within the past several decades, techniques that accurately measure regional cerebral blood flow have been developed. At the present time, the inert gas washout technique using an intraarterial injection of 133Xe with the Anger scintillation camera or multiple probes as the external detector is the most established of these methods. While quantitative measures of cerebral blood flow have been important in elucidating the physiology of cerebral hemodynamics, the techniques are too invasive for routinely screening patients with cerebrovascular disease. As a result, less invasive methods have been sought for diagnostic screening. Because it requires only an intravenous injection of 99mTc-pertechnetate, the radionuclide cerebral angiogram has achieved some popularity as a semiquantitative measure of cerebral hemodynamics, particularly when coupled with static brain scintigraphy. This review examines our current understanding of cerebral hemodynamics and the advantages and limitations of techniques used to measure cerebral blood flow.
在过去几十年里，已经开发出了能够精确测量局部脑血流量的技术。目前，使用动脉内注射133Xe并以安格闪烁照相机或多个探头作为外部探测器的惰性气体洗脱技术是这些方法中最成熟的。虽然脑血流量的定量测量在阐明脑血流动力学的生理学方面很重要，但这些技术对于常规筛查脑血管疾病患者来说侵入性太大。因此，人们一直在寻找侵入性较小的诊断筛查方法。由于只需要静脉注射高锝[99mTc]酸盐，放射性核素脑血管造影作为一种脑血流动力学的半定量测量方法已经受到了一定程度的欢迎，特别是与静态脑闪烁显像结合使用时。这篇综述探讨了我们目前对脑血流动力学的理解以及用于测量脑血流量的技术的优缺点。
