Hørlyck A, Henriques U, Jakobsen A
Department of Oncology, Aarhus University Hospital, Denmark.
Acta Oncol. 1994;33(8):909-11. doi: 10.3109/02841869409098455.
Of 668 consecutive patients with SCLC, 472 underwent bone marrow examination for staging. In 330 patients a triple examination (sternal aspiration, iliac crest aspiration and biopsy) was performed, otherwise a single procedure. Bone marrow infiltration (MI) was found in 37% of the patients with extensive disease, and the frequencies of a positive finding in single and triple examination were not statistically different. In the group having triple examination performed iliac crest aspiration alone disclosed MI in 32%. When all three procedures were included still more patients with MI were found (42%) but the two values were not significantly different. In 6.6% of patients who would have been classified as 'limited' did bone marrow examination change the stage to extensive disease. Based on these results we recommend iliac crest aspiration, but not triple examination with iliac crest biopsy, in the staging of SCLC.
在668例连续的小细胞肺癌患者中，472例接受了骨髓检查以进行分期。330例患者进行了三联检查（胸骨穿刺、髂嵴穿刺和活检），否则进行单项检查。在广泛期疾病患者中，37%发现骨髓浸润（MI），单项检查和三联检查阳性发现的频率无统计学差异。在进行三联检查的组中，仅髂嵴穿刺发现32%的患者有MI。当包括所有三项检查时，发现有MI的患者更多（42%），但这两个值无显著差异。在6.6%原本会被归类为“局限期”的患者中，骨髓检查将分期改为广泛期。基于这些结果，我们建议在小细胞肺癌分期中采用髂嵴穿刺，而非髂嵴活检的三联检查。
