Clatch R J, Krigman H R, Peters M G, Zutter M M
Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110.
Br J Haematol. 1994 Dec;88(4):685-92. doi: 10.1111/j.1365-2141.1994.tb05105.x.
To validate scientifically our prior empiric observations that patients develop significant haemopoietic dysplasia following solid organ transplantation, we developed a quantitative lineage-specific scoring system to evaluate dysplastic features of bone marrow aspirates and core biopsies. We used this scoring system to compare retrospectively randomly selected bone marrow aspirates and core biopsies from 19 patients undergoing orthotopic liver transplantation (OLT), 21 with a known history of human immunodeficiency virus (HIV) infection, and 18 with primary or chemotherapy-related myelodysplastic syndromes (MDS). Our results show that the OLT patient group developed significant but milder haemopoietic dysplastic changes than the HIV or MDS groups, and that the MDS group developed more severe dysplasia of the myeloid lineage than the other groups. The possible roles for drugs and infectious agents in the pathophysiology of dysplastic changes are discussed.
为了科学验证我们之前的经验性观察结果，即实体器官移植后患者会出现显著的造血发育异常，我们开发了一种定量的谱系特异性评分系统，以评估骨髓穿刺液和活检组织的发育异常特征。我们使用该评分系统对19例接受原位肝移植（OLT）的患者、21例有人类免疫缺陷病毒（HIV）感染病史的患者以及18例原发性或化疗相关骨髓增生异常综合征（MDS）患者的随机抽取的骨髓穿刺液和活检组织进行回顾性比较。我们的结果表明，OLT患者组出现了显著但比HIV或MDS组更轻微的造血发育异常变化，并且MDS组的髓系谱系发育异常比其他组更严重。文中讨论了药物和感染因子在发育异常变化病理生理学中的可能作用。
