Kaloutsi V, Kohlmeyer U, Maschek H, Nafe R, Choritz H, Amor A, Georgii A
Pathologisches Institut, Medizinischen Hochschule, Hannover, Germany.
Am J Clin Pathol. 1994 Feb;101(2):123-9. doi: 10.1093/ajcp/101.2.123.
The histologic, hematologic, and morphometric findings of 40 patients positive for the human immunodeficiency virus (HIV) were compared statistically with those of 40 patients with primary myelodysplastic syndromes (MDS) and those of 32 HIV-negative patients with infectious diseases. The severity of anemia and the abnormalities of erythropoiesis in the group of HIV patients were less pronounced than in the group with MDS; megakaryopoiesis showed similarities only with the group of patients with infectious diseases, and characteristics of dysplasia were not observed. Granulopoiesis in MDS showed an increase of blasts in several cases; this was not found in any biopsy specimen from the HIV group. In addition, a statistically significant increase of monocyte-like cells and giant bands could be observed in the bone marrow of the HIV patients. The peripheral blood findings and bone marrow picture in the series of our HIV patients appeared to be related mainly to the influence of opportunistic infections, although a direct effect of the HIV itself could not be excluded.
对40例人类免疫缺陷病毒（HIV）阳性患者的组织学、血液学和形态学检查结果，与40例原发性骨髓增生异常综合征（MDS）患者以及32例HIV阴性传染病患者的检查结果进行了统计学比较。HIV患者组贫血的严重程度和红细胞生成异常程度比MDS组轻；巨核细胞生成仅与传染病患者组有相似之处，未观察到发育异常特征。MDS中的粒细胞生成在几例病例中显示原始细胞增加；HIV组的任何活检标本中均未发现这种情况。此外，在HIV患者的骨髓中可观察到单核细胞样细胞和巨大带在统计学上有显著增加。我们这组HIV患者的外周血检查结果和骨髓情况似乎主要与机会性感染的影响有关，尽管不能排除HIV本身的直接作用。
