Wolinsky T D, Carr K D, Hiller J M, Simon E J
Millhauser Laboratories, Department of Psychiatry, New York University Medical Center, NY 10016.
Brain Res. 1994 Sep 12;656(2):274-80. doi: 10.1016/0006-8993(94)91470-2.
It was previously observed that chronic food restriction lowers the threshold for lateral hypothalamic self-stimulation in a manner that is reversible by mu- and kappa-selective opioid antagonists. The present quantitative autoradiographic study was designed to investigate whether chronic food restriction alters regional mu and kappa opioid binding in brain. [3H]DAGO (mu) and mu/delta blocked [3H]BMZ (kappa) binding were analyzed in 34 brain regions from the medial prefrontal cortex to posterior hypothalamus. Significant reductions in mu binding were observed in caudal portions of the medial and lateral habenula, and the basolateral and basomedial nuclei of the amygdala. kappa binding was similarly reduced in medial habenula. Large increases in kappa binding were observed in the bed nucleus of the stria terminalis, ventral pallidum, and medial preoptic area. The possible involvement of these changes in the sensitization of reward by food restriction is discussed.
先前观察到，长期食物限制会降低外侧下丘脑自我刺激的阈值，且这种降低可被μ和κ选择性阿片受体拮抗剂逆转。本定量放射自显影研究旨在调查长期食物限制是否会改变大脑中μ和κ阿片受体的区域结合情况。对从内侧前额叶皮质到下丘脑后部的34个脑区进行了[3H]DAGO（μ）和μ/δ阻断的[3H]BMZ（κ）结合分析。在内侧和外侧缰核的尾部以及杏仁核的基底外侧和基底内侧核中观察到μ结合显著减少。内侧缰核中的κ结合也有类似减少。在终纹床核、腹侧苍白球和内侧视前区观察到κ结合大幅增加。讨论了这些变化可能参与食物限制引起的奖赏敏化的情况。
