台湾地区除环丙沙星外使用其他氟喹诺酮类药物后耐甲氧西林葡萄球菌中的氟喹诺酮耐药性

Fluoroquinolone resistance among methicillin-resistant staphylococci after usage of fluoroquinolones other than ciprofloxacin in Taiwan.

作者信息

Chang S C, Hsieh W C, Luh K T

机构信息

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Republic of China.

出版信息

Diagn Microbiol Infect Dis. 1994 Jul;19(3):143-7. doi: 10.1016/0732-8893(94)90056-6.

DOI:10.1016/0732-8893(94)90056-6

PMID:7820993

Abstract

The antimicrobial susceptibility to norfloxacin, ofloxacin, and ciprofloxacin of methicillin-resistant staphylococci isolated before and after the use of fluoroquinolones other than ciprofloxacin in Taiwan was studied by the agar dilution method. Before the use of fluoroquinolones, 54 isolates of methicillin-resistant Staphylococcus aureus (MRSA) and 51 isolates of methicillin-resistant coagulase-negative staphylococci (MRCNS) isolated in 1983-1985 were all susceptible to the three fluoroquinolones tested. Following the use of norfloxacin, enoxacin, and ofloxacin, the MIC90s of norfloxacin, ofloxacin, and ciprofloxacin against 46 isolates of MRSA collected during 1989-1990 increased to 64, 16, and 32 micrograms/ml, respectively, and the rates of resistant strains to these three agents were 37.0%, 30.4%, and 34.8%, respectively. The MIC90s against 42 isolates of MRCNS also increased to 64, 8, and 8 micrograms/ml, respectively, with 35.7%, 23.8%, and 33.3% resistant strains.

摘要

采用琼脂稀释法，研究了台湾地区在使用除环丙沙星之外的氟喹诺酮类药物前后分离出的耐甲氧西林葡萄球菌对诺氟沙星、氧氟沙星和环丙沙星的抗菌敏感性。在使用氟喹诺酮类药物之前，1983 - 1985年分离出的54株耐甲氧西林金黄色葡萄球菌（MRSA）和51株耐甲氧西林凝固酶阴性葡萄球菌（MRCNS）对所检测的三种氟喹诺酮类药物均敏感。在使用诺氟沙星、依诺沙星和氧氟沙星之后，1989 - 1990年收集的46株MRSA对诺氟沙星、氧氟沙星和环丙沙星的MIC90s分别增至64、16和32微克/毫升，对这三种药物的耐药菌株率分别为37.0%、30.4%和34.8%。对42株MRCNS的MIC90s也分别增至64、8和8微克/毫升，耐药菌株率分别为35.7%、23.8%和33.3%。