Alexander J W, Korelitz J, Alexander N S
Am J Surg. 1976 Jul;132(1):59-63. doi: 10.1016/0002-9610(76)90291-9.
Fluids collecting in surgical wounds in both dogs and man have been shown to lose progressively the ability to opsonize bacteria for phagocytosis and killing of bacteria by normal neutrophils. Since the collection of fluids in potentially contaminated wounds also interferes with access of phagocytic cells to contaminating bacteria and provides a pablum for growth, their removal seems to be indicated to minimize the risk of infection. This can be accomplished easily and safely with the use of closed suction drainage as demonstrated in 100 patients undergoing bilateral nephrectomy, splenectomy, and renal transplantation.
在狗和人类身上，手术伤口中积聚的液体已被证明会逐渐丧失调理细菌以便正常中性粒细胞进行吞噬和杀灭细菌的能力。由于潜在污染伤口中液体的积聚也会干扰吞噬细胞接触污染细菌，并为细菌生长提供养分，因此似乎有必要将其清除，以将感染风险降至最低。如对100例接受双侧肾切除术、脾切除术和肾移植手术的患者所做的示范那样，使用封闭式负压引流可以轻松且安全地做到这一点。
