Seki K, Furuya K, Makimura N, Mitsui C, Hirata J, Nagata I
Department of Obstetrics and Gynecology, National Defense Medical College, Tokorozawa, Japan.
J Perinat Med. 1994;22(3):189-94. doi: 10.1515/jpme.1994.22.3.189.
We measured cord blood levels of calcium-regulating hormones and osteocalcin in 34 premature infants of various gestational ages. 1,25(OH)2D levels were low in mid-gestation and increased with advancing gestation. Parathyroid hormone levels were low, and calcitonin levels were high in mid-gestation. Both of them declined with advancing gestation. Osteocalcin levels were high in mid-gestation. They increased from 22 weeks through 27 weeks of gestational age, and decreased thereafter. Circulating osteocalcin is considered as a clinical marker of bone turnover. However, cord blood osteocalcin decreased between 27 and 36 weeks of gestation during which period calcium accumulation by the fetus increases. Therefore, cord blood osteocalcin does not appear to reflect fetal bone formation.
我们检测了34名不同孕周的早产儿脐带血中钙调节激素和骨钙素的水平。孕中期1,25(OH)₂D水平较低，且随着孕周增加而升高。甲状旁腺激素水平较低，而降钙素水平在孕中期较高。二者均随孕周增加而下降。骨钙素水平在孕中期较高。其在孕22周27周期间升高，之后下降。循环骨钙素被认为是骨转换的临床标志物。然而，在孕27周36周期间，胎儿钙蓄积增加，但脐带血骨钙素却下降。因此，脐带血骨钙素似乎不能反映胎儿的骨形成情况。
