Seki K, Makimura N, Mitsui C, Hirata J, Nagata I
Department of Obstetrics and Gynecology, National Defense Medical College, Saitama, Japan.
Am J Obstet Gynecol. 1991 May;164(5 Pt 1):1248-52. doi: 10.1016/0002-9378(91)90694-m.
We measured serum concentrations of calcium-regulating hormones and osteocalcin in 20 women longitudinally throughout pregnancy, 1,25-Dihydroxyvitamin D levels were high early in pregnancy and increased with advancing gestation. Parathyroid hormone and osteocalcin levels were low in early pregnancy. They declined toward the middle of pregnancy, but increased in late pregnancy. The serum osteocalcin level correlated with the parathyroid hormone level. The synthesis of osteocalcin by osteoblasts is stimulated by the action of 1,25-dihydroxyvitamin D, and serum osteocalcin levels are also related to the levels of parathyroid hormone. During early and mid pregnancy, the stimulatory effect of 1,25-dihydroxyvitamin D on the synthesis of osteocalcin may be overridden by the inhibitory effect of declining parathyroid hormone levels. The increase in osteocalcin level in late pregnancy may be a consequence of increasing levels of both parathyroid hormone and 1,25-dihydroxyvitamin D.
我们纵向测量了20名女性在整个孕期血清中钙调节激素和骨钙素的浓度。1,25-二羟维生素D水平在孕早期较高，并随着孕周增加而升高。甲状旁腺激素和骨钙素水平在孕早期较低。它们在孕中期下降，但在孕晚期升高。血清骨钙素水平与甲状旁腺激素水平相关。成骨细胞合成骨钙素受1,25-二羟维生素D的作用刺激，血清骨钙素水平也与甲状旁腺激素水平有关。在孕早期和中期，1,25-二羟维生素D对骨钙素合成的刺激作用可能被甲状旁腺激素水平下降的抑制作用所抵消。孕晚期骨钙素水平的升高可能是甲状旁腺激素和1,25-二羟维生素D水平均升高的结果。
