Gauze G F, Laĭko A V, Selezneva T I
Antibiotiki. 1976 Jul;21(7):591-3.
The mutants of Saccharomyces cerevisiae, strain FL 599-I B with defect cell membranes are selectively inhibited by anticancer antibiotics with different molecular mechanisms of action on DNA. At the same time they are insensitive to antibacterial antibiotics. Such mutants may be used as test-cultures in isolation of active agents with antitumor effect from complex mixtures of natural substances. The above test-object makes it easier to perform separation of antimour antibiotics from accompanying bacterial inhibitors.
酿酒酵母菌株FL 599-I B的细胞膜有缺陷的突变体，可被对DNA有不同作用分子机制的抗癌抗生素选择性抑制。同时，它们对抗菌抗生素不敏感。这类突变体可用作从天然物质复杂混合物中分离具有抗肿瘤作用的活性剂的试验培养物。上述试验对象便于从伴随的细菌抑制剂中分离抗瘤抗生素。
